KMID : 0383820080650050390
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Tuberculosis and Respiratory Diseases 2008 Volume.65 No. 5 p.390 ~ p.395
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Efficacy of Long-term Interferon-alpha Therapy in Adult Patients with Recurrent Respiratory Papillomatosis
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Nam Hae-Seong
Koh Won-Jung Suh Gee-Young Chung Man-Pyo Kwon O-Jung Kim Ho-Joong
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Abstract
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Background: Since the early 1980s, interferon-alpha (IFN-¥á) has been used as adjuvant therapy in pediatric patients with recurrent respiratory papillomatosis (RRP). However, its efficacy in adults needs to be validated. Since 2002, Samsung Medical Center¡¯s guidelines have mandated regular injection of IFN-¥á in patients with RRP to prevent recurrence. To evaluate these guidelines, patient data were investigated.
Methods: Five patients diagnosed as having RRP by bronchoscopy and histopathology were included. After initial bronchoscopic intervention, including laser cauterization, all patients received subcutaneous injection of 6 million units of IFN-¥á every 2 months. Further bronchoscopic intervention was carried out as needed. Patients were regularly evaluated using bronchoscopy or computed tomography.
Results: The median age of the patients was 44 years (range 13¡68), and the median duration of papillomatosis was 31 years (range 1¡45). Three and two patients had juvenile-onset and adult-onset disease, respectively. Two patients had a history of tracheostomy at the time of diagnosis. The median duration of IFN-¥á therapy was 56 months (range 12¡66). Two patients showed complete remission at 12 and 36 months after IFN-¥á injection, respectively. The other three patients showed partial remission, and the number of laser therapy
sessions was significantly reduced.
Conclusion: Intermittent IFN-¥á injection is effective in patients with long-standing RRP and can reduce the number of laser therapy sessions required in their treatment.
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KEYWORD
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Adjuvant therapy, Interferon-alpha, Recurrent respiratory papillomatosis
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